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SYRE - Spyre Therapeutics, Inc.


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Spyre Therapeutics, Inc., headquartered in Waltham, Massachusetts, operates as an innovative biotechnology firm dedicated to advancing breakthrough antibody therapeutics tailored for the treatment of inflammatory bowel disease (IBD). Founded in 2013 and formerly known as Aeglea BioTherapeutics, Inc., the company rebranded to Spyre Therapeutics, Inc. in November 2023 to reflect its renewed focus and expanded commitment to pioneering therapeutic advancements in the field of immunology.

Spyre Therapeutics leverages a multidisciplinary approach that integrates cutting-edge antibody engineering, rational therapeutic combinations, and precision medicine strategies for patient selection. This comprehensive methodology underpins the development of its robust pipeline, which features extended half-life antibodies targeting key pathways such as a4ß7, TL1A, and IL-23. These therapeutic candidates hold promise in addressing the complex mechanisms associated with IBD, aiming to improve treatment outcomes and enhance patient quality of life.

The company's dedication to scientific excellence is underscored by its collaborative efforts with leading research institutions and healthcare professionals. Spyre Therapeutics continues to drive innovation through strategic partnerships and collaborations, accelerating the development of novel biologic therapies that address unmet medical needs in gastrointestinal disorders. By prioritizing rigorous clinical research and regulatory compliance, Spyre Therapeutics strives to bring transformative therapies to market swiftly and responsibly.

With a forward-thinking vision and a commitment to advancing patient care, Spyre Therapeutics remains at the forefront of the biotechnology sector. By harnessing the power of precision medicine and next-generation antibody technologies, the company aims to establish a robust portfolio of therapeutic solutions that redefine standards of care in IBD and beyond. Spyre Therapeutics' relentless pursuit of scientific innovation positions it as a key player in shaping the future of biopharmaceutical advancements worldwide.

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