ERAS Profile
Erasca, Inc. is a clinical-stage biopharmaceutical company dedicated to the discovery, development, and commercialization of innovative therapies targeting cancers driven by the RAS/MAPK signaling pathway. This pathway is implicated in a range of malignancies, making it a critical focus for Erasca’s therapeutic development efforts. The company's pipeline includes several promising drug candidates designed to address unmet medical needs in oncology.
Among Erasca’s lead therapeutic candidates is ERAS-007, an oral inhibitor specifically targeting ERK1/2. This compound is being developed for the treatment of several challenging cancers, including non-small cell lung cancer (NSCLC), colorectal cancer, and acute myeloid leukemia (AML). ERAS-007 aims to disrupt cancer cell proliferation by inhibiting a key component of the RAS/MAPK pathway, potentially offering new treatment options for patients with these aggressive cancers.
Another significant candidate in Erasca’s pipeline is ERAS-601, an oral inhibitor of SHP2. This drug is designed for patients with advanced or metastatic solid tumors, addressing a critical need for effective therapies in difficult-to-treat cancer cases. By targeting SHP2, ERAS-601 seeks to block a crucial signaling mechanism that supports tumor growth and survival. Additionally, Erasca is developing ERAS-801, a central nervous system-penetrant inhibitor of EGFR, intended for patients with recurrent glioblastoma multiforme, a highly aggressive form of brain cancer. ERAS-801 aims to penetrate the blood-brain barrier and provide therapeutic benefits in a challenging oncology setting.
Founded in 2018 and headquartered in San Diego, California, Erasca, Inc. has quickly positioned itself at the forefront of targeted cancer therapy development. The company’s focus on the RAS/MAPK pathway and related targets reflects a strategic approach to addressing complex cancer mechanisms. Erasca’s commitment to advancing its drug candidates through clinical development underscores its dedication to improving outcomes for cancer patients and addressing significant gaps in current treatment options. By leveraging cutting-edge science and innovative drug development strategies, Erasca aims to make a substantial impact in the field of oncology.
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